Updated November 5, 2011

VECTRA™ DA

• Allaart CF, Dirven L, Hirata S, Kerstens PJSM, Dijkmans BAC, Chernoff D, Cavet G, Centola M, Hesterberg LK, Tanaka Y. Huizinga TWJ, and Shen Y. A Multi-Biomarker Disease Activity (Vectra DA) Algorithm Score for Rheumatoid Arthritis Predicts Radiographic Progression in the BeSt Study. Oral Presentation 1613. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• van der Helm-van Mil AHM, Knevel R, Qureshi F, Manning WC, Cavet G, Huizinga TWJ and Haney DJ. Evaluation of Definitions of Rheumatoid Arthritis Remission by Assessing Radiographic Progression in the Leiden Early Arthritis Cohort. Poster 323. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• Ma MH, Ramanujan S, Cavet G, Haney DJ, Zhao X, Eastman PS, Kingsley GH, Scott DL and Cope AP. Investigation of a Multi-Biomarker Disease Activity (Vectra DA) Signature and Algorithm Score in Rheumatoid Arthritis Patients with Low Disease Activity: The REMIRA Study. Poster 361. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• Hirata S, Dirven L, Cavet G, Shen Y, Centola M, Lems WL, Huizinga TWJ, Allaart CF, and Tanaka Y. A Novel Multi-Biomarker Disease Activity Score (Vectra™DA algorithm score) Reflects Clinical Disease Activity Score and Health Assessment Questionnaire for Rheumatoid Arthritis in the BeSt Study. Poster 351. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• Hirata S, Haney DJ, Cavet G, Hesterberg LK, Sawamukai N, Yamaoka K, Saito K, and Tanaka Y. A Multi-Biomarker Disease Activity Score (Vectra™DA algorithm score) Reflects Clinical Disease Activity and Tracks Response in a Japanese Rheumatoid Arthritis Population Treated with Anti-TNF Therapy. Poster 2244. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• Weinblatt ME, Shadick NA, Manning W, Coblyn JS, Centola M, Chernoff D, Cavet G, Haney DJ. Use of a Multi-Biomarker Score for Rheumatoid Arthritis Disease Activity (Vectra™ DA) to Assess Response to Therapy. (Poster Session I: May 26, 2011, 11:45 BST). EULAR Congress 2011.
  
  
• Allaart CF, Dirven L, Hirata S, Kerstens PJ, Dijkmans BA, Chernoff D, Cavet G, Centola M, Hesterberg LK, Tanaka Y, Huizinga TW, Shen Y. A Multi-Biomarker Algorithm for RA Disease Activity (Vectra™ DA) Predicts Radiographic Progression in the BeSt Study. (Poster Session I: May 26, 201, 11:45 BST). EULAR Congress 2011.
  
  
• Shadick NA, Chernoff D, Hamburger M, Curtis JR, Cavet G, Ford K, Swan K, Haney DJ. Robustness of a Novel Multi-Biomarker Score for RA Disease Activity (Vectra™ DA) Across a Spectrum of Co-Morbidities and Smoking Status. (Poster Session II: May 27, 2011, 11:45 BST). EULAR Congress 2011.
  
  
• Hirata S, Dirven L, Shen Y, Centola M, Cavet G, Lems WF, Tanaka Y, Huizinga TW, Allaart CF. A Multi-Biomarker Based Disease Activity (MBDA) Score System Compared to a Conventional Disease Activity Score (DAS) System in the BeSt Rheumatoid Arthritis (RA) Study. (Poster Session III: May 28, 2011, 10:15 BST). EULAR Congress 2011.
  
  
• Ma MH, Ramanujan S, Haney DJ, Cavet G, Kingsley GH, Scott DL, Cope AP. Biomarker Signatures in Rheumatoid Arthritis Patients with Low Disease Activity: The REMIRA Study. (Poster Session III: May 28, 2011, 10:15 BST). EULAR Congress 2011.
  
  
• Curtis JR, Haney D, van der Helm A HM, Shen Y, Knevel R, Cavet G, Dirven L, Allaart CF, Huizinga T WJ, Centola M, Hesterberg LK, Chernoff D, Carulli J,Shadick NA, Weinblatt ME, Hamburger MI, Fleischmann RM, Keystone EC. Validation of a Multi-Biomarker Test for Rheumatoid Arthritis (RA) Disease Activity (Vectra™ DA) in a Multi-Cohort Study. Presentation 1782. ACR 2010 Annual Scientific Meeting.
  
  
• Bakker MF, Shen Y, Bijlsma J WJ, Jacobs J WG, Lafeber F PJG, Cavet G, Centola M, Haney D, Hesterberg LK, Chernoff D, Carulli J, Shadick NA, Weinblatt ME, Hamburger MI, Fleischmann RM, Curtis JR, Keystone EC. Development of a Multi-Biomarker Test for Rheumatoid Arthritis (RA) Disease Activity (Vectra™ DA). Presentation 1753. ACR 2010 Annual Scientific Meeting.
  
  
• Cavet G, Centola M, Shen Y, Haney D, Smith D, Hesterberg L, Chernoff D, Carulli J, Shadick NA, Weinblatt ME, Hamburger M, Fleischmann R, Keystone EC, Curtis JR and The InFoRM and BRASS Study Groups. Development of a Multi-Biomarker Test for Rheumatoid Arthritis (RA) Disease Activity. Oral Presentation # EULAR2010-SCIE-3851. EULAR Congress 2010. Ann Rheum Dis. 2010; 69 ( Suppl 3):148.
  
  
• Bakker MF, Bijlsma JWJ, Jacobs JWG, Haney D, Shen Y, Hesterberg LK, Smith D, Centola M, Lafeber FPJG, Cavet G. Performance of Serum Biomarkers and Multivariate Biomarker-Based Test to Measure Disease Activity in Early Rheumatoid Arthritis Treated According to the CAMERA Protocol. Poster # FRI0106. EULAR Congress 2010.
  
  
• Fleischmann R, Curtis JR, Hamburger M, Blumstein H, Swan K, Cavet G, Chernoff D on behalf of the InFoRM Study Group. RA Population Characteristics in InFoRM: a Longitudinal Observational Study. Poster # SAT0518. EULAR Congress 2010.
  
  
• Ramanujan S, Centola M, Cavet G, McInnes I. Multi-Protein Biomarker Panel Integrates Critical Pathophysiologic Mechanisms in Measurement of RA Disease Activity. Poster # FRI0034. EULAR Congress 2010.
  
  
• Shen Y, Knowlton N, Turner M, Sutton C, Smith D, Chernoff D, Hesterberg LK, Carulli J, Shadick NA, Weinblatt ME, Cavet G, Centola M. Stepwise Discovery of Disease Activity Biomarkers in Rheumatoid Arthritis. Poster # THU0066. EULAR Congress 2010.
  
  
• Shen Y, Knowlton N, Turner M, Sutton C, Smith D, Chernoff D, Hesterberg L, Roubenoff R, Shadick NA, Weinblatt M, Cavet G, Centola M. Stepwise development of a multi-protein biomarker index of RA disease activity.Presentation 345. ACR 2009 Annual Scientific Meeting.
  
  

PIPELINE PRODUCTS

• der Helm-van Mil AHM, Knevel R, Manning WC, Hesterberg LK, Cavet G, Huizinga TWJ, and Shen Y. Development of a Multi-Biomarker Structural Damage Score in Rheumatoid Arthritis to Predict Radiographic Progression in the Leiden Early Arthritis Cohort. Oral Presentation 838. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• van der Helm-van Mil AH, Knevel R, Manning W, Hesterberg LK, Cavet G, Huizinga TW, Shen Y. Development of A Multi-Biomarker Algorithm to Predict RA Structural Damage in the Leiden Early Arthritis Cohort. Ann Rheum Dis 2011;70(Suppl3):350.
  
  
• Shen Y, Dirven L, Cavet G, Centola M, Dijkmans B A C, Hesterberg LK, Huizinga T, Lems WF, Allaart CF. Serum Biomarkers Predict Progressive Structural Damage in the BeSt Study [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1496.
  
  
• Knowlton N, Giles JT, Wages J, Payne A, Cavet G, Centola M, Alaupovic P, Bathon JM. Elevations in APOC-III Contraining Apolipoprotein Complexes Predict Progression of Coronary Atherosclerosis in Patients With Rheumatoid Arthritis. Ann Rheum Dis 2010;69(Suppl3):111.
  
  
• Cavet C, Shen Y, Abraham S, Chernoff D, Hesterberg LK, Centola M, Taylor P. A Comparison of Serum and Urine Biomarkers for Predicting Radiographic Progression in Rheumatoid Arthritis. Ann Rheum Dis 2010;69(Suppl3):304.
  
  
• Shen Y, Dirven L, Cavet G, Centola M, Dijkmans BAK, Hesterberg LK, Kerstens PJSM, Huizinga TWJ, Allaart CF. Serum Biomarkers Predict Progressive Structural Damage in the BeSt Study. Ann Rheum Dis 2010;69(Suppl3):501.
  
  
• Cavet G, Shen Y, Abraham S, Chernoff D, Centola M, Taylor P. Predicting radiographic progression in rheumatoid arthritis with ultrasound and biomarkers[abstract]. Arthritis Rheum 2009;60 Suppl 10 :1464.
  
  
• Alaupovic P, Giles JT, Knowlton N, Payne A, Cavet G, Centola M, Bathon JM. The apolipoprotein complex LpAII:B:C:D:E is increased in rheumatoid arthritis and is associated with carotid atherosclerosis[abstract]. Arthritis Rheum 2009;60 Suppl 10 :602.
  
  

ASSAY PERFORMANCE

• Zhao X, Eastman PS, Qureshi F, Manning WC, Robinson W, and Hesterberg LK. Development of a High-Throughput, Multiplex Assay for Profiling the Autoantibody Fine Specificity in Rheumatoid Arthritis. Poster 1748. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• Qureshi F, Manning W, Eastman S, Hu W, Centola M, Turner M, Carson CW, Kumar AA, Zacharias LA, Alexander C, Haney D, Cavet G, Hesterberg LK. Pre Analytical Effects of Serum Collection and Handling in Quantitative Immunoassays for Rheumatoid Arthritis [abstract]. Arthritis Rheum 2010;62 Suppl 10:1606.
  
  
• Eastman S, Manning B, Qureshi F, Cavet G, Haney D, Shen Y, Alexander C, Fleischmann R, Hesterberg LK. Assay Development for Precise Measurement of Disease Activity Serum Biomarkers. Ann Rheum Dis 2010;69(Suppl3):170.
  
  
• Knowlton N, Todd DJ, Karlson EW, Shadick NA, Weinblatt ME, Schur PH, Roubenoff R, Izmailova E, Cavet G, Centola M, Lee DM. Rheumatoid Factor Interferes With Multiplex Immunoassays in Rheumatoid Arthritis Patients. Ann Rheum Dis 2010;69(Suppl3):171.
  
  

AMERICAN COLLEGE OF RHEUMATOLOGY (ACR) - 2011 ANNUAL SCIENTIFIC MEETING

• Allaart CF, Dirven L, Hirata S, Kerstens PJSM, Dijkmans BAC, Chernoff D, Cavet G, Centola M, Hesterberg LK, Tanaka Y. Huizinga TWJ, and Shen Y. A Multi-Biomarker Disease Activity (Vectra DA) Algorithm Score for Rheumatoid Arthritis Predicts Radiographic Progression in the BeSt Study. Oral Presentation 1613. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• der Helm-van Mil AHM, Knevel R, Manning WC, Hesterberg LK, Cavet G, Huizinga TWJ, and Shen Y. Development of a Multi-Biomarker Structural Damage Score in Rheumatoid Arthritis to Predict Radiographic Progression in the Leiden Early Arthritis Cohort. Oral Presentation 838. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• van der Helm-van Mil AHM, Knevel R, Qureshi F, Manning WC, Cavet G, Huizinga TWJ and Haney DJ. Evaluation of Definitions of Rheumatoid Arthritis Remission by Assessing Radiographic Progression in the Leiden Early Arthritis Cohort. Poster 323. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• Ma MH, Ramanujan S, Cavet G, Haney DJ, Zhao X, Eastman PS, Kingsley GH, Scott DL and Cope AP. Investigation of a Multi-Biomarker Disease Activity (Vectra DA) Signature and Algorithm Score in Rheumatoid Arthritis Patients with Low Disease Activity: The REMIRA Study. Poster 361. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• Hirata S, Dirven L, Cavet G, Shen Y, Centola M, Lems WL, Huizinga TWJ, Allaart CF, and Tanaka Y. A Novel Multi-Biomarker Disease Activity Score (Vectra$trade;DA algorithm score) Reflects Clinical Disease Activity Score and Health Assessment Questionnaire for Rheumatoid Arthritis in the BeSt Study. Poster 351. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• Hirata S, Haney DJ, Cavet G, Hesterberg LK, Sawamukai N, Yamaoka K, Saito K, and Tanaka Y. A Multi-Biomarker Disease Activity Score (Vectra$trade;DA algorithm score) Reflects Clinical Disease Activity and Tracks Response in a Japanese Rheumatoid Arthritis Population Treated with Anti-TNF Therapy. Poster 2244. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  
• Zhao X, Eastman PS, Qureshi F, Manning WC, Robinson W, and Hesterberg LK. Development of a High-Throughput, Multiplex Assay for Profiling the Autoantibody Fine Specificity in Rheumatoid Arthritis. Poster 1748. ACR 2011 Annual Scientific Meeting, Chicago, IL.
  
  

AMERICAN COLLEGE OF RHEUMATOLOGY (ACR) - 2010 ANNUAL SCIENTIFIC MEETING

• Curtis JR, Haney D, van der Helm A HM, Shen Y, Knevel R, Cavet G, Dirven L, Allaart CF, Huizinga T WJ, Centola M, Hesterberg LK, Chernoff D, Carulli J, Shadick NA, Weinblatt ME, Hamburger MI, Fleischmann RM, Keystone EC. Validation of a Multi-Biomarker Test for Rheumatoid Arthritis (RA) Disease Activity (Vectra™ DA) in a Multi-Cohort Study. Presentation 1782. ACR 2010 Annual Scientific Meeting.
  
  
• Bakker MF, Shen Y, Bijlsma J WJ, Jacobs J WG, Lafeber F PJG, Cavet G, Centola M, Haney D, Hesterberg LK, Chernoff D, Carulli J, Shadick NA, Weinblatt ME, Hamburger MI, Fleischmann RM, Curtis JR, Keystone EC. Development of a Multi-Biomarker Test for Rheumatoid Arthritis (RA) Disease Activity (Vectra™ DA). Presentation 1753. ACR 2010 Annual Scientific Meeting.
  
  
• Shen Y, Dirven L, Cavet G, Centola M, Dijkmans B A C, Hesterberg LK, Huizinga T, Lems WF, Allaart CF. Serum Biomarkers Predict Progressive Structural Damage in the BeSt Study. Presentation 1496. ACR 2010 Annual Scientific Meeting.
  
  
• Qureshi F, Manning W, Eastman S, Hu W, Centola M, Turner M, Carson CW, Kumar AA, Zacharias LA, Alexander C, Haney D, Cavet G, Hesterberg LK. Pre Analytical Effects of Serum Collection and Handling in Quantitative Immunoassays for Rheumatoid Arthritis. Presentation 1606. ACR 2010 Annual Scientific Meeting.
  
  

AMERICAN COLLEGE OF RHEUMATOLOGY (ACR) - 2009 ANNUAL SCIENTIFIC MEETING

• Shen Y, Knowlton N, Turner M, Sutton C, Smith D, Chernoff D, Hesterberg L, Roubenoff R, Shadick NA, Weinblatt M, Cavet G, Centola M. Stepwise development of a multi-protein biomarker index of RA disease activity. Presentation 345.
  
  
• Alaupovic P, Giles JT, Knowlton N, Payne A, Cavet G, Centola M, Bathon JM. The apolipoprotein complex LpAII:B:C:D:E is increased in rheumatoid arthritis and is associated with carotid atherosclerosis. Presentation 602.
  
  
• Cavet G, Shen Y, Abraham S, Chernoff D, Centola M, Taylor P. Predicting radiographic progression in rheumatoid arthritis with ultrasound and biomarkers. Presentation 1464.
  
  

AMERICAN COLLEGE OF RHEUMATOLOGY (ACR) - 2008 ANNUAL SCIENTIFIC MEETING

• Turner M, Knowlton N, Frank MB, et al. Development of a multivariate disease activity test in rheumatoid arthritis. Presentation 1955.
  
  

EUROPEAN LEAGUE AGAINST RHEUMATISM (EULAR) CONGRESS 2011

• Weinblatt ME, Shadick NA, Manning W, Coblyn JS, Centola M, Chernoff D, Cavet G, Haney DJ. Use of a Multi-Biomarker Score for Rheumatoid Arthritis Disease Activity (Vectra(TM) DA) to Assess Response to Therapy. (Poster Session I: May 26, 2011, 11:45 BST). EULAR Congress 2011.
  
  
• Allaart CF, Dirven L, Hirata S, Kerstens PJ, Dijkmans BA, Chernoff D, Cavet G, Centola M, Hesterberg LK, Tanaka Y, Huizinga TW, Shen Y. A Multi-Biomarker Algorithm for RA Disease Activity (Vectra™ DA) Predicts Radiographic Progression in the BeSt Study. (Poster Session I: May 26, 201, 11:45 BST). EULAR Congress 2011.
  
  
• Shadick NA, Chernoff D, Hamburger M, Curtis JR, Cavet G, Ford K, Swan K, Haney DJ. Robustness of a Novel Multi-Biomarker Score for RA Disease Activity (Vectra™ DA) Across a Spectrum of Co-Morbidities and Smoking Status. (Poster Session II: May 27, 2011, 11:45 BST). EULAR Congress 2011.
  
  
• Hirata S, Dirven L, Shen Y, Centola M, Cavet G, Lems WF, Tanaka Y, Huizinga TW, Allaart CF. A Multi-Biomarker Based Disease Activity (MBDA) Score System Compared to a Conventional Disease Activity Score (DAS) System in the BeSt Rheumatoid Arthritis (RA) Study. (Poster Session III: May 28, 2011, 10:15 BST). EULAR Congress 2011.
  
  
• Ma MH, Ramanujan S, Haney DJ, Cavet G, Kingsley GH, Scott DL, Cope AP. Biomarker Signatures in Rheumatoid Arthritis Patients with Low Disease Activity: The REMIRA Study. (Poster Session III: May 28, 2011, 10:15 BST). EULAR Congress 2011.
  
  
• van der Helm-van Mil AH, Knevel R, Manning W, Hesterberg LK, Cavet G, Huizinga TW, Shen Y. Development of A Multi-Biomarker Algorithm to Predict RA Structural Damage in the Leiden Early Arthritis Cohort. (Poster Session II: May 27, 2011, 11:45 BST) EULAR Congress 2011.
  
  

EUROPEAN LEAGUE AGAINST RHEUMATISM (EULAR) CONGRESS 2010

• Cavet G, Centola M, Shen Y, Haney D, Smith D, Hesterberg L, Chernoff D, Carulli J, Shadick NA, Weinblatt ME, Hamburger M, Fleischmann R, Keystone EC, Curtis JR and The InFoRM and BRASS Study Groups. Development of a Multi-Biomarker Test for Rheumatoid Arthritis (RA) Disease Activity.Oral Presentation # EULAR2010-SCIE-3851. EULAR Congress 2010. Ann Rheum Dis. 2010; 69 ( Suppl 3):148.
  
  
• Knowlton N, Giles JT, Wages J, Payne A, Cavet G, Centola M, Alaupovic P, Bathon JM. Elevations in APOC-III Contraining Apolipoprotein Complexes Predict Progression of Coronary Atherosclerosis in Patients With Rheumatoid Arthritis. Oral Presentation # EULAR2010-SCIE-4267. EULAR Congress 2010.
  
  
• Eastman S, Manning B, Qureshi F, Cavet G, Haney D, Shen Y, Alexander C, Fleischmann R, Hesterberg LK. Assay Development for Precise Measurement of Disease Activity Serum Biomarkers. Poster # THU0065.
  
  
• Shen Y, Knowlton N, Turner M, Sutton C, Smith D, Chernoff D, Hesterberg LK, Carulli J, Shadick NA, Weinblatt ME, Cavet G, Centola M. Stepwise Discovery of Disease Activity Biomarkers in Rheumatoid Arthritis. Poster # THU0066.
  
  
• Knowlton N, Todd DJ, Karlson EW, Shadick NA, Weinblatt ME, Schur PH, Roubenoff R, Izmailova E, Cavet G, Centola M, Lee DM. Rheumatoid Factor Interferes With Multiplex Immunoassays in Rheumatoid Arthritis Patients. Poster # THU0067.
  
  
• Cavet C, Shen Y, Abraham S, Chernoff D, Hesterberg LK, Centola M, Taylor P. A Comparison of Serum and Urine Biomarkers for Predicting Radiographic Progression in Rheumatoid Arthritis. Poster # THU0485.
  
  
• Ramanujan S, Centola M, Cavet G, McInnes I. Multi-Protein Biomarker Panel Integrates Critical Pathophysiologic Mechanisms in Measurement of RA Disease Activity. Poster # FRI0034.
  
  
• Bakker MF, Bijlsma JWJ, Jacobs JWG, Haney D, Shen Y, Hesterberg LK, Smith D, Centola M, Lafeber FPJG, Cavet G. Performance of Serum Biomarkers and Multivariate Biomarker-Based Test to Measure Disease Activity in Early Rheumatoid Arthritis Treated According to the CAMERA Protocol. Poster # FRI0106.
  
  
• Shen Y, Dirven L, Cavet G, Centola M, Dijkmans BAK, Hesterberg LK, Kerstens PJSM, Huizinga TWJ, Allaart CF. Serum Biomarkers Predict Progressive Structural Damage in the BeSt Study. Poster # SAT0049.
  
  
• Fleischmann R, Curtis JR, Hamburger M, Blumstein H, Swan K, Cavet G, Chernoff D on behalf of the InFoRM Study Group. RA Population Characteristics in InFoRM: a Longitudinal Observational Study. Poster # SAT0518.