Selected References Supporting Crescendo's Vision and Mission
Note: These are provided for background only and are not intended to suggest claims about the accuracy or reliability of any Crescendo tests.
Tight Control
Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Kerstens PJ, et al. DAS-driven therapy versus routine care in patients with recent-onset active Rheumatoid Arthritis. Ann Rheum Dis. 2009 Jan 20. Epub ahead of print.
Grigor C, Capell H, Stirling A, et al. Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomized controlled trial. Lancet. 2004;364(9430):263-9.
Sokka T, Mäkinen H, Puolakka K, et al. Remission as the treatment goal — the FIN-RACo trial. Clin Exp Rheumatol. 2006;24(6 Suppl 43):S-74-6.
Verstappen SM, Jacobs JW, van der Veen MJ, et al. Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Ann Rheum Dis. 2007;66(11):1443-9. Epub 2007 May 22.
Quantitative Biology
Alex P, Szodoray P, Knowlton N, et al. Multiplex serum cytokine monitoring as a prognostic tool in rheumatoid arthritis. Clin Exp Rheumatol. 2007;25(4):584-92.
Brennan FM, McInnes IB. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest. 2008;118(11):3537-45.
Centola M, Frank MB, Bolstad AI, et al. Genome-scale assessment of molecular pathology in systemic autoimmune diseases using microarray technology: a potential breakthrough diagnostic and individualized therapy-design tool. Scand J Immunol. 2006;64(3):236-42.
Emery P, Gabay C, Kraan M, et al. Evidence-based review of biologic markers as indicators of disease progression and remission in rheumatoid arthritis. Rheumatol Int. 2007;27(9):793-806. Epub 2007 May 16.
Saad F. Optimizing patient therapy: the role of bone markers? Cancer Treat Rev. 2006;32 Suppl 1:3-6.
Szodoray P, Alex P, Chappell-Woodward CM, et al. Circulating cytokines in Norwegian patients with psoriatic arthritis determined by a multiplex cytokine array system. Rheumatology (Oxford). 2007;46(3):417-25. Epub 2006 Aug 27.
Szodoray P, Alex P, Frank MB, et al. A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis. Rheumatology (Oxford). 2006;45(12):1466-76. Epub 2006 Apr 25.
Robust Assay Development
He YD, Dai H, Schadt EE, et al. Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics. 2003;19(8):956-65.
Simon R. Development and validation of biomarker classifiers for treatment selection. J Stat Plan Inference. 2008;138(2):308-320.